Cutaneous Neural Neoplasms by Zsolt Argenyi & Chris H. Jokinen

Author:Zsolt Argenyi & Chris H. Jokinen
Language: eng
Format: epub
Publisher: Humana Press, Totowa, NJ

Fig. 4.70Plexiform cellular schwannoma, congenital type: the Schwann cells are otherwise typical of schwannoma, with slender tapered nuclei and uniform fine chromatin

Fig. 4.71S-100 protein in plexiform cellular schwannoma: the neoplastic cells of this and all variants of schwannoma show strong and diffuse nuclear and cytoplasmic staining. This differs from neurofibroma in which most (but not all) express this marker

Pseudoglandular schwannoma is a rare morphologic variant of schwannoma, where the Schwann cells are arranged in tubular or gland-like structures (Figs. 4.72–4.74). These are true Schwann cells and not epithelial cells, demonstrated by immunohistochemical reactivity for S-100 protein, and negative staining for cytokeratins (Fig. 4.75). True glandular schwannoma as described represents a schwannoma with admixed epithelial glands. It is uncertain if this represents a form of bilineal differentiation or, more likely, entrapment of existing adnexal (eccrine or apocrine) glands.

Fig. 4.72Pseudoglandular schwannoma: a circumscribed dermal mass with a thick capsule and multiple ecstatic spaces resembling epithelial glands

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